On November 24, 2025, President Donald Trump signed an executive order to launch the “Genesis Mission,” a comprehensive initiative intended to enhance innovation through the application of artificial intelligence (AI). This order builds on Trump’s earlier initiatives, including the executive order from January 23, 2025, titled “Removing Barriers to American Leadership in Artificial Intelligence,” as well as the “Winning the Race, America’s AI Action Plan” released in July 2025. According to the U.S. Department of Energy (DOE), the Genesis Mission aims to address three critical challenges of national importance: American energy dominance, advancing discovery science, and ensuring national security.
The mission’s first goal is to promote American energy dominance by accelerating advancements in nuclear power, fusion, and grid modernization through AI. This approach is designed to provide affordable and reliable energy solutions across the country. Secondly, the Genesis Mission will seek to advance discovery science by investing in the “quantum ecosytem,” a collaborative effort between the DOE and the private sector aimed at facilitating scientific breakthroughs in the AI field. Lastly, the mission will enhance national security by developing AI technologies to support the safety and integrity of the U.S. nuclear stockpile and expedite the creation of “defense-ready” materials.
The Genesis Mission has been positioned as a coordinated national effort led by the DOE, marking a significant shift in how the U.S. approaches scientific research and innovation. The initiative is designed to unify federal scientific datasets, supercomputing resources, and research infrastructures into a cohesive AI platform. This platform will facilitate foundational model training, hypothesis testing, and the automation of research workflows. The executive order likens this mission to the urgency and ambition of the Manhattan Project, seeking to radically transform scientific discovery, bolster national security, enhance workforce productivity, and maximize returns on federal research and development investments.
Key Tasks and Objectives
The execution of this ambitious initiative will be overseen by the Secretary of Energy, who has been explicitly designated as the lead for the Genesis Mission within the DOE. This role includes setting priorities and appointing a senior political appointee to manage day-to-day operations. The strategy has been notably influenced by recommendations from the National Security Commission on Emerging Biotechnology (NSCEB), which emphasized the necessity of a coordinated federal approach to leverage national laboratories and integrate scientific resources. Although the EO does not explicitly cite NSCEB, its strategy reflects the spirit of those recommendations.
The American Science and Security Platform is a crucial component of this mission, designated to provide high-performance computing capabilities, AI modeling frameworks, secure data access, and tools for autonomous experimentation. The executive order outlines the specific capabilities required, including AI agents, domain-specific foundation models, and automated manufacturing workflows, and sets forth deadlines for identifying necessary computing resources and data assets.
Priority domains for the Genesis Mission encompass advanced manufacturing, biotechnology, critical materials, nuclear energy, quantum information science, semiconductors, and microelectronics. The executive order insists that these areas must align with the National Science and Technology Memorandum No. 2.
Partnerships will play a pivotal role in the Genesis Mission, fostering collaboration with academia, private sectors, and international partners while ensuring robust security and intellectual property protections. The executive order mandates standardized partnership frameworks, uniform cybersecurity and vetting standards, and clear policies regarding ownership, licensing, and trade-secret protections. Annual progress reports will be generated to monitor operational status and scientific advancements, thereby promoting transparency and accountability.
The Genesis Mission’s reliance on the DOE’s national laboratories signifies a direct response to NSCEB’s recommendations, which warned that the U.S. risks losing its competitive edge in biotechnology without leveraging existing lab infrastructure. The executive order encompasses a broader scientific mission, aiming to overcome fragmentation in federal research efforts while accelerating progress across critical scientific domains.
As the initiative unfolds, the Secretary of Energy will coordinate closely with the Assistant to the President for Science and Technology, who is responsible for aligning national objectives and maximizing impact through interagency collaboration. The mission’s success will depend significantly on effective implementation, as well as ongoing support from policymakers and stakeholders, both in Congress and across various sectors.
Ultimately, the Genesis Mission represents an ambitious effort to harness AI for scientific advancement while ensuring national security and energy sustainability. Its success could redefine the landscape of American scientific research and international competitiveness in the field of artificial intelligence.
U.S. Department of Energy | White House | National Institute of Standards and Technology
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