Generative AI, while celebrated for its ability to analyze data and propose scientific ideas, faces significant limitations in its creative capabilities, according to recent research. A study led by Professor Amy Wenxuan Ding of emlyon business school and Professor Shibo Li of Indiana University indicates that, although AI can mimic scientific reasoning, it lacks the imaginative leaps that drive genuine discovery.
The study utilized a computer-simulated experiment to challenge ChatGPT-4 with a genuine genetics puzzle, asking it to propose hypotheses, design experiments, and revise its thinking based on experimental results. While the model effectively managed the mechanics of scientific reasoning, its breakthroughs were modest and often accompanied by misplaced confidence.
Professor Ding articulated her motivations for exploring this domain, stating, “My research has been driven by a fascination with the origin of intelligence in both humans and machines.” Inspired by Isaac Newton’s seminal work, the team aimed to develop computational models to mirror the creative thought processes characteristic of human scientists.
The researchers noted that, more than two decades ago, they began investigating how humans make scientific discoveries. They created computational systems that could replicate this process in specific scientific fields. However, these systems struggled with a crucial limitation: a lack of true understanding. The advent of generative AI marked a potential turning point, as machines began to grasp human language meaning more effectively than ever before, prompting the researchers to test whether such a model could navigate the complexities of scientific reasoning.
When asked if public expectations of AI’s scientific abilities are inflated, Ding remarked, “It’s not so much overestimation as it is a misunderstanding of how AI functions.” She explained that AI’s performance is contingent upon the ability to convert domain knowledge into a digital format without losing essential meaning. Fields like mathematics and biology, with established symbolic structures, allow AI to excel. In contrast, traits such as imagination and curiosity, which lack clear computable representations, remain beyond AI’s reach.
The experiment was designed to minimize instructional bias, allowing the AI to autonomously trigger the scientific loop of hypothesis generation, experiment design, result interpretation, and revision. Ding emphasized the importance of observing if science could emerge without explicit commands. Genetics was chosen as the focus due to its structured yet complex nature, representing a high-stakes domain where AI could potentially contribute significantly to human knowledge.
In the experiment, the AI was tasked with investigating a Nobel-level biological challenge, functioning akin to a scientist in a virtual laboratory. It was expected to propose hypotheses, design tests, and adjust its approach based on results. However, the findings revealed that the AI could only make incremental discoveries without demonstrating any signs of learning throughout the study.
Ding explained that curiosity in a scientific context encompasses more than a desire to know; it involves an instinct to pursue anomalies and contemplate possibilities beyond established knowledge. Current AI, she noted, operates based on external reward functions, lacking the intrinsic motivation that drives human inquiry. Until a mathematical representation of curiosity is developed, AI will remain an optimizer of known goals rather than a seeker of new ones.
Looking toward the future, Ding envisions a collaborative rather than combative relationship between human and machine creativity in science. She described an evolving model where “Human-Orchestrated, Machine-Executed” interactions define the scientific landscape. Humans will set the exploration parameters, while machines can traverse these dimensions at unprecedented speeds. In this framework, the human provides the high-level intent, while generative AI serves as a high-velocity explorer.
Ding remains cautiously optimistic about the potential for AI to develop capabilities akin to human curiosity. She acknowledges that curiosity in humans stems from emotion and lived experiences—attributes currently absent in AI. However, she believes future models may mimic curiosity sufficiently to contribute meaningfully to scientific discovery.
As the boundaries of generative AI continue to be tested, the research serves as a reminder of both the tool’s potential and its limitations. This interplay between human ingenuity and machine capabilities will be pivotal in shaping the future of scientific exploration.
See also
US Customs Proposes Mandatory 5-Year Social Media History for 42 Countries’ Tourists
Trump’s Executive Order Blocks State AI Regulations, Favours Tech Giants Amid Innovation Race
Tech Titans Face Tough Scrutiny in Historic AI Regulation Hearing on Capitol Hill
Oracle Faces $360B Loss Amid OpenAI Dependency Concerns and Rising Costs
Tech Giants Unveil “Athena”: Revolutionary AI Model Set to Transform Industries


















































